Gene

pikfyve

ID

ZDB-GENE-030131-9636

Name

phosphoinositide kinase, FYVE finger containing

Symbol

pikfyve Nomenclature History

Previous Names

pip5k3
wu:fo93c03

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have 1-phosphatidylinositol-3-phosphate 5-kinase activity; ATP binding activity; and metal ion binding activity. Predicted to be involved in intracellular signal transduction; phosphatidylinositol metabolic process; and phosphorylation. Localizes to membrane and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Is expressed in several structures, including brain; digestive system; eye; muscle; and pleuroperitoneal region. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu745 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pikfyve Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fleck corneal dystrophy	Alliance	Corneal fleck dystrophy	121850

Associated With pikfyve Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	pikfyve^shz1/+ (AB)	standard conditions	Mei et al., 2022
cataract	pikfyve^shz1/shz1 (AB)	standard conditions	Mei et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000306	FYVE zinc finger
Domain	IPR000591	DEP domain
Domain	IPR002498	Phosphatidylinositol-4-phosphate 4/5-kinase, core
Domain	IPR017455	Zinc finger, FYVE-related
Domain	IPR037378	PIKfyve, DEP domain
Domain	IPR044769	1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain
Family	IPR002423	Chaperonin Cpn60/GroEL/TCP-1 family
Family	IPR043548	1-phosphatidylinositol-3phosphate-5-kinase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR027409	GroEL-like apical domain superfamily
Homologous_superfamily	IPR027483	Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
Homologous_superfamily	IPR027484	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	1-phosphatidylinositol-3phosphate-5-kinase	1-phosphatidylinositol-3-phosphate 5-kinase, PIPK catalytic domain	Chaperonin Cpn60/GroEL/TCP-1 family	DEP domain	FYVE zinc finger	GroEL-like apical domain superfamily	Phosphatidylinositol-4-phosphate 4/5-kinase, core	Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily	Phosphatidylinositol-4-phosphate 5-kinase, N-terminal	PIKfyve, DEP domain	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily	Zinc finger, FYVE/PHD-type	Zinc finger, FYVE-related	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M3B5N9 InterPro	2105
UniProtKB:A0A8M3B2P6 InterPro	2095
UniProtKB:A0A8M2BF26 InterPro	2104
UniProtKB:A0A8M3BCH5 InterPro	2117
UniProtKB:B2KTE1 InterPro	2100
UniProtKB:B2KTE4 InterPro	2075
UniProtKB:B2KTE2 InterPro	2084
UniProtKB:A0A8M3AW35 InterPro	1838
UniProtKB:A0A8M3AW30 InterPro	2121
UniProtKB:A0A8M3AW23 InterPro	2112
UniProtKB:B2KTE3 InterPro	2091

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	pikfyve-205 (1) Ensembl	Ensembl	866 nt	Select Tool
mRNA	pikfyve-201 (1) Ensembl	Ensembl	6,276 nt	Select Tool ZFIN BLAST
mRNA	pikfyve-202 (1) Ensembl	Ensembl	8,698 nt	Select Tool ZFIN BLAST
mRNA	pikfyve-203 (1) Ensembl	Ensembl	6,303 nt	Select Tool
mRNA	pikfyve-204 (1) Ensembl	Ensembl	6,933 nt	Select Tool
mRNA	pikfyve-206 (1) Ensembl	Ensembl	6,238 nt	Select Tool
mRNA	pikfyve-207 (1) Ensembl	Ensembl	8,813 nt	Select Tool ZFIN BLAST
mRNA	pikfyve-208 (1) Ensembl	Ensembl	8,861 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations