Gene

coro1a

ID

ZDB-GENE-030131-9512

Name

coronin, actin binding protein, 1A

Symbol

coro1a Nomenclature History

Previous Names

fj83g12
wu:fj83g12 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Involved in brain development; central nervous system projection neuron axonogenesis; and eye development. Human ortholog(s) of this gene implicated in coronin-1A deficiency. Is expressed in several structures, including ball; hematopoietic cell; hematopoietic system; pronephros; and thymus. Orthologous to human CORO1A (coronin 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 10 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63766 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Blaker-Lee et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With coro1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
coronin-1A deficiency	Alliance	Immunodeficiency 8	615401

Associated With coro1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR015048	Domain of unknown function DUF1899
Family	IPR015505	Coronin
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat