Gene
mettl3
- ID
- ZDB-GENE-030131-9498
- Name
- methyltransferase like 3
- Symbol
- mettl3 Nomenclature History
- Previous Names
-
- fj82g07
- wu:fj82g07
- zgc:77093
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Exhibits mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity and mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including Notch signaling pathway involved in arterial endothelial cell fate commitment; endothelial to hematopoietic transition; and hematopoietic stem cell proliferation. Predicted to localize to RNA N6-methyladenosine methyltransferase complex and nuclear speck. Used to study infertility. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human METTL3 (methyltransferase like 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77093 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- 19 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| infertility | mettl3ihb307/ihb307 (AB) | standard conditions | Xia et al., 2017 |
| infertility | mettl3ihb306/ihb306 (AB) | standard conditions | Xia et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | MT-A70-like | N6-adenosine-methyltransferase MT-A70-like | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
|
UniProtKB:F1R777
|
584 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mettl3-201
(1)
|
Ensembl | 1,997 nt | ||
| ncRNA |
mettl3-002
(1)
|
Ensembl | 684 nt |
Interactions and Pathways
No data available
Plasmids
No data available