Gene

alox5ap

ID

ZDB-GENE-030131-9322

Name

arachidonate 5-lipoxygenase-activating protein

Symbol

alox5ap Nomenclature History

Previous Names

Flap (1)
wu:fj65d02
zgc:63982

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to enable glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With alox5ap Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebral infarction	Alliance	{Stroke, susceptibility to}	601367

Associated With alox5ap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001129	Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Family	IPR001446	5-lipoxygenase-activating protein
Family	IPR050997	Membrane-associated proteins in eicosanoid and glutathione metabolism
Homologous_superfamily	IPR023352	Membrane associated eicosanoid/glutathione metabolism-like domain superfamily