Gene
rars1
- ID
- ZDB-GENE-030131-9014
- Name
- arginyl-tRNA synthetase 1
- Symbol
- rars1 Nomenclature History
- Previous Names
-
- rars
- wu:fa96g09
- zgc:86730
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Is expressed in digestive system; immature eye; myotome; nervous system; and somite. Orthologous to human RARS1 (arginyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56050 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypomyelinating leukodystrophy 9 | Alliance | Leukodystrophy, hypomyelinating, 9 | 616140 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
| Domain | IPR005148 | Arginyl tRNA synthetase N-terminal domain |
| Domain | IPR008909 | DALR anticodon binding |
| Domain | IPR035684 | Arginyl-tRNA synthetase, catalytic core domain |
| Family | IPR001278 | Arginine-tRNA ligase |
| Homologous_superfamily | IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
| Homologous_superfamily | IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Homologous_superfamily | IPR036695 | Arginyl tRNA synthetase N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding | Aminoacyl-tRNA synthetase, class I, conserved site | Arginine-tRNA ligase | Arginyl-tRNA synthetase, catalytic core domain | Arginyl tRNA synthetase N-terminal domain | Arginyl tRNA synthetase N-terminal domain superfamily | DALR anticodon binding | Rossmann-like alpha/beta/alpha sandwich fold |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7ZVF4
|
661 | ||||||||
|
UniProtKB:A0A8M6Z3L7
|
595 |
Interactions and Pathways
No data available
Plasmids
No data available