Gene

mpzl2b

ID

ZDB-GENE-030131-8774

Name

myelin protein zero-like 2b

Symbol

mpzl2b Nomenclature History

Previous Names

mpzl2
cb837 (1)
eva1
wu:fb07b02 (1)

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Enables identical protein binding activity. Acts upstream of or within regulation of basement membrane organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; epidermis; periderm; pronephric duct; and sensory system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 111. Orthologous to human MPZL2 (myelin protein zero like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb837 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Jayadev et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mpzl2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 111	Alliance	Deafness, autosomal recessive 111	618145

Associated With mpzl2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR000920	Myelin P0 protein-related
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Immunoglobulin domain subtype	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin V-set domain	Myelin P0 protein-related
UniProtKB:Q8JG36 InterPro	199

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mpzl2b-201 (1) Ensembl	Ensembl	1,608 nt	Select Tool ZFIN BLAST
ncRNA	mpzl2b-002 (1) Ensembl	Ensembl	528 nt	Select Tool ZFIN BLAST
ncRNA	mpzl2b-003 (1) Ensembl	Ensembl	1,344 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations