Gene
atp2a2b
- ID
- ZDB-GENE-030131-867
- Name
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2b
- Symbol
- atp2a2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable P-type calcium transporter activity. Acts upstream of or within determination of heart left/right asymmetry. Predicted to be located in sarcoplasmic reticulum. Predicted to be active in membrane. Is expressed in axis; myotome; pectoral fin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu338 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Shim et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acrokeratosis verruciformis | Alliance | Acrokeratosis verruciformis | 101900 |
| keratosis follicularis | Alliance | Darier disease | 124200 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004014 | Cation-transporting P-type ATPase, N-terminal |
| Domain | IPR006068 | Cation-transporting P-type ATPase, C-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR005782 | P-type ATPase, subfamily IIA, SERCA-type |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Length | Cation-transporting P-type ATPase, C-terminal | Cation-transporting P-type ATPase, N-terminal | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IIA, SERCA-type | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IQS8
|
1041 | |||||||||||
|
UniProtKB:Q6ZM60
|
1035 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp2a2b-201
(1)
|
Ensembl | 4,312 nt | ||
| mRNA |
atp2a2b-202
(1)
|
Ensembl | 5,913 nt | ||
| mRNA |
atp2a2b-203
(1)
|
Ensembl | 5,808 nt |
Interactions and Pathways
No data available
Plasmids
No data available