Gene

hadhb

ID

ZDB-GENE-030131-8550

Name

hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta

Symbol

hadhb Nomenclature History

Previous Names

fb14g10
wu:fb14g10
zgc:56274 (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have transferase activity, transferring acyl groups other than amino-acyl groups. Human ortholog(s) of this gene implicated in mitochondrial metabolism disease and mitochondrial trifunctional protein deficiency. Is expressed in female organism. Orthologous to human HADHB (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56274 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hadhb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial trifunctional protein deficiency 2	Alliance	Mitochondrial trifunctional protein deficiency 2	620300

Associated With hadhb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR020610	Thiolase, active site
Active_site	IPR020615	Thiolase, acyl-enzyme intermediate active site
Conserved_site	IPR020613	Thiolase, conserved site
Domain	IPR020616	Thiolase, N-terminal
Domain	IPR020617	Thiolase, C-terminal
Family	IPR002155	Thiolase
Homologous_superfamily	IPR016039	Thiolase-like

Domain Details Per Protein

Protein	Length	Thiolase	Thiolase, active site	Thiolase, acyl-enzyme intermediate active site	Thiolase, conserved site	Thiolase, C-terminal	Thiolase-like	Thiolase, N-terminal
UniProtKB:Q7ZTH6 InterPro	471

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	hadhb-201 (1) Ensembl	Ensembl		6,981 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations