Gene

ptprja

ID

ZDB-GENE-030131-8301

Name

protein tyrosine phosphatase receptor type Ja

Symbol

ptprja Nomenclature History

Previous Names

density-enhanced phosphatase-1a (1)
dep1a (1)
fb08b12
wu:fb08b12 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Involved in artery morphogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Is expressed in blood vessel endothelial cell; brain; and muscle. Orthologous to human PTPRJ (protein tyrosine phosphatase receptor type J).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ptprja Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	Colon cancer, somatic	114500
		Thrombocytopenia 10	620484

Associated With ptprja Via Experimental Models

Human Disease	Fish	Conditions	Citations
thrombocytopenia	la2Tg + CRISPR2-ptprja	standard conditions	Marconi et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR016130	Protein-tyrosine phosphatase, active site
Domain	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain
Domain	IPR000387	Tyrosine-specific protein phosphatases domain
Domain	IPR003595	Protein-tyrosine phosphatase, catalytic
Domain	IPR003961	Fibronectin type III
Domain	IPR041201	PTPRJ, transmembrane domain
Family	IPR050713	Receptor-type Tyrosine-protein Phosphatases/Ushers
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR029021	Protein-tyrosine phosphatase-like
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	Protein-tyrosine phosphatase, active site	Protein-tyrosine phosphatase, catalytic	Protein-tyrosine phosphatase-like	PTPRJ, transmembrane domain	Receptor-type Tyrosine-protein Phosphatases/Ushers	Tyrosine-specific protein phosphatase, PTPase domain	Tyrosine-specific protein phosphatases domain
UniProtKB:A0A8M2BE01 InterPro	1766
UniProtKB:A0A8M9Q1N4 InterPro	1683
UniProtKB:B6HY54 InterPro	1650
UniProtKB:A0A8M2BDT9 InterPro	1766

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ptprja-203 (1) Ensembl	Ensembl	5,618 nt	Select Tool ZFIN BLAST
ncRNA	ptprja-002 (1) Ensembl	Ensembl	493 nt	Select Tool ZFIN BLAST
ncRNA	ptprja-003 (1) Ensembl	Ensembl	423 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations