Gene
grm1a
- ID
- ZDB-GENE-030131-7893
- Name
- glutamate receptor, metabotropic 1a
- Symbol
- grm1a Nomenclature History
- Previous Names
-
- fj39d05
- si:ch211-51a19.1
- wu:fj39d05
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; glutamate receptor activity; and neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway and regulation of glutamatergic synaptic transmission. Predicted to localize to integral component of plasma membrane and postsynaptic density membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Is expressed in brain and retinal neural layer. Orthologous to human GRM1 (glutamate metabotropic receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 13 | Alliance | Spinocerebellar ataxia, autosomal recessive 13 | 614831 |
| spinocerebellar ataxia 44 | Alliance | Spinocerebellar ataxia 44 | 617691 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017979 | GPCR, family 3, conserved site |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR011500 | GPCR, family 3, nine cysteines domain |
| Domain | IPR017978 | GPCR family 3, C-terminal |
| Domain | IPR019588 | Metabotropic glutamate receptor, Homer-binding domain |
| Family | IPR000162 | GPCR, family 3, metabotropic glutamate receptor |
| Family | IPR000337 | GPCR, family 3 |
| Family | IPR001256 | GPCR, family 3, metabotropic glutamate receptor 1 |
| Family | IPR050726 | Metabotropic Glutamate Receptor |
| Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
| Homologous_superfamily | IPR038550 | GPCR, family 3, nine cysteines domain superfamily |
Domain Details Per Protein
| Protein | Length | GPCR, family 3 | GPCR, family 3, conserved site | GPCR family 3, C-terminal | GPCR, family 3, metabotropic glutamate receptor | GPCR, family 3, metabotropic glutamate receptor 1 | GPCR, family 3, nine cysteines domain | GPCR, family 3, nine cysteines domain superfamily | Metabotropic Glutamate Receptor | Metabotropic glutamate receptor, Homer-binding domain | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATC9
|
939 | |||||||||||
|
UniProtKB:A0A2R9YJL7
|
1153 |
Interactions and Pathways
No data available
Plasmids
No data available