Gene

lrp1aa

ID

ZDB-GENE-030131-7889

Name

low density lipoprotein receptor-related protein 1Aa

Symbol

lrp1aa Nomenclature History

Previous Names

lrp1a
si:dkey-40c23.4
wu:fj39b01

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable apolipoprotein binding activity. Acts upstream of or within regulation of vasculature development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in blood vessel and caudal vein plexus. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7142928 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Pi et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrp1aa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
keratosis pilaris atrophicans	Alliance	?Keratosis pilaris atrophicans	604093
		Developmental dysplasia of the hip 3	620690

Associated With lrp1aa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Conserved_site	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR026823	Complement Clr-like EGF domain
Domain	IPR032485	Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR051221	Low-density lipoprotein receptor-related
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR036055	LDL receptor-like superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR000033	LDLR class B repeat
Repeat	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat

Domain Details Per Protein

Protein	Length	Complement Clr-like EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	LDLR class B repeat	LDL receptor-like superfamily	Low-density lipoprotein (LDL) receptor class A, conserved site	Low-density lipoprotein (LDL) receptor class A repeat	Low-density lipoprotein receptor-related	NOTCH1 EGF-like calcium-binding domain	Prolow-density lipoprotein receptor-related protein 1-like, beta-propeller domain	Six-bladed beta-propeller, TolB-like
UniProtKB:A0A8M9QD95 InterPro	4560

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	lrp1aa-201 (1) Ensembl	Ensembl	4,949 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-202 (1) Ensembl	Ensembl	13,518 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-203 (1) Ensembl	Ensembl	3,571 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-204 (1) Ensembl	Ensembl	3,053 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-205 (1) Ensembl	Ensembl	1,685 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-206 (1) Ensembl	Ensembl	309 nt	Select Tool ZFIN BLAST
mRNA	lrp1aa-207 (1) Ensembl	Ensembl	582 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations