Gene

sema3e

ID
ZDB-GENE-030131-7864
Name
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
Symbol
sema3e Nomenclature History
Previous Names
  • fj37c11
  • si:ch211-120m13.2
  • wu:fj37c11
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits neuropilin binding activity. Involved in sprouting angiogenesis. Predicted to localize to extracellular space and integral component of plasma membrane. Is expressed in several structures, including brain; cardiovascular system; endoderm; mandibular arch skeleton; and primary motor neurons. Human ortholog(s) of this gene implicated in CHARGE syndrome. Orthologous to human SEMA3E (semaphorin 3E).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sema3e Human Ortholog
No data available
Associated With sema3e Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001627 Sema domain
Domain IPR003599 Immunoglobulin domain subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013151 Immunoglobulin-like beta-sandwich domain
Domain IPR015513 Semaphorin 3E, Sema domain
Domain IPR016201 PSI domain
Family IPR027231 Semaphorin
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Homologous_superfamily IPR036352 Sema domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin domain subtype Immunoglobulin-like beta-sandwich domain Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold PSI domain Sema domain Sema domain superfamily Semaphorin Semaphorin 3E, Sema domain WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M9PQA6 767
UniProtKB:Q1LYS1 768
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA sema3e-201 (1) Ensembl 3,044 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations