Gene

pon2

ID

ZDB-GENE-030131-7116

Name

paraoxonase 2

Symbol

pon2 Nomenclature History

Previous Names

fk84f07
wu:fk84f07
zgc:77556

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have arylesterase activity. Human ortholog(s) of this gene implicated in artery disease (multiple); neurodegenerative disease (multiple); type 2 diabetes mellitus; and vascular dementia. Is expressed in cranium. Orthologous to several human genes including PON2 (paraoxonase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77556 (2 images)
IMAGE:6911665 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pon2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Coronary artery disease, susceptibility to}

Associated With pon2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR002640	Arylesterase
Family	IPR051288	Serum paraoxonase/arylesterase
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Homologous_superfamily	IPR011045	Nitrous oxide reductase, N-terminal