Gene
wasb
- ID
- ZDB-GENE-030131-7098
- Name
- WASP actin nucleation promoting factor b
- Symbol
- wasb Nomenclature History
- Previous Names
-
- was
- wasp1 (1)
- wu:fk81c08
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have actin filament binding activity. Involved in macrophage chemotaxis; neutrophil chemotaxis; and regulation of neutrophil migration. Predicted to localize to actin cortical patch and actin filament. Used to study Wiskott-Aldrich syndrome. Human ortholog(s) of this gene implicated in Wiskott-Aldrich syndrome and severe congenital neutropenia. Is expressed in hematopoietic system; leukocyte; neuromast; thrombocyte; and thymus. Orthologous to human WAS (WASP actin nucleation promoting factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64164 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked | 313900 |
| thrombocytopenia | Alliance | Thrombocytopenia, X-linked, intermittent | 313900 |
| Wiskott-Aldrich syndrome | Alliance | Wiskott-Aldrich syndrome | 301000 |
| X-linked severe congenital neutropenia | Alliance | Neutropenia, severe congenital, X-linked | 300299 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Wiskott-Aldrich syndrome | wasbhu3280/hu3280 | standard conditions | Jones et al., 2013 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000095 | CRIB domain |
| Domain | IPR000697 | WH1/EVH1 domain |
| Domain | IPR003124 | WH2 domain |
| Domain | IPR033927 | WASP family, EVH1 domain |
| Homologous_superfamily | IPR011026 | Actin nucleation-promoting factor WAS, C-terminal |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036936 | CRIB domain superfamily |
Domain Details Per Protein
| Protein | Length | Actin nucleation-promoting factor WAS, C-terminal | CRIB domain | CRIB domain superfamily | PH-like domain superfamily | WASP family, EVH1 domain | WH1/EVH1 domain | WH2 domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T318
|
479 |
Interactions and Pathways
No data available
Plasmids
No data available