Gene
glula
- ID
- ZDB-GENE-030131-688
- Name
- glutamate-ammonia ligase (glutamine synthase) a
- Symbol
- glula Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and glutamate-ammonia ligase activity. Predicted to be involved in glutamine biosynthetic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; musculature system; and nervous system. Orthologous to human GLUL (glutamate-ammonia ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 57 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb195 (14 images)
- cb757 (34 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital glutamine deficiency | Alliance | Glutamine deficiency, congenital | 610015 |
| developmental and epileptic encephalopathy 116 | Alliance | Developmental and epileptic encephalopathy 116 | 620806 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR027302 | Glutamine synthetase, N-terminal conserved site |
| Conserved_site | IPR027303 | Glutamine synthetase, glycine-rich site |
| Domain | IPR008146 | Glutamine synthetase, catalytic domain |
| Domain | IPR008147 | Glutamine synthetase, N-terminal domain |
| Family | IPR050292 | Glutamine Synthetase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
| Homologous_superfamily | IPR036651 | Glutamine synthetase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Glutamine Synthetase | Glutamine synthetase, catalytic domain | Glutamine synthetase, glycine-rich site | Glutamine synthetase/guanido kinase, catalytic domain | Glutamine synthetase, N-terminal conserved site | Glutamine synthetase, N-terminal domain | Glutamine synthetase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2P7
|
371 |
Interactions and Pathways
No data available
Plasmids
No data available