Gene
glula
- ID
- ZDB-GENE-030131-688
- Name
- glutamate-ammonia ligase (glutamine synthase) a
- Symbol
- glula Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable glutamate-ammonia ligase activity. Predicted to be involved in glutamine biosynthetic process. Predicted to act upstream of or within nitrogen compound metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; musculature system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; and temporal lobe epilepsy. Orthologous to human GLUL (glutamate-ammonia ligase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 58 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb195 (14 images)
- cb757 (34 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital glutamine deficiency | Alliance | Glutamine deficiency, congenital | 610015 |
| developmental and epileptic encephalopathy 116 | Alliance | Developmental and epileptic encephalopathy 116 | 620806 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR027302 | Glutamine synthetase, N-terminal conserved site |
| Conserved_site | IPR027303 | Glutamine synthetase, glycine-rich site |
| Domain | IPR008146 | Glutamine synthetase, catalytic domain |
| Domain | IPR008147 | Glutamine synthetase, N-terminal domain |
| Family | IPR050292 | Glutamine Synthetase |
| Homologous_superfamily | IPR014746 | Glutamine synthetase/guanido kinase, catalytic domain |
| Homologous_superfamily | IPR036651 | Glutamine synthetase, N-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Glutamine Synthetase | Glutamine synthetase, catalytic domain | Glutamine synthetase, glycine-rich site | Glutamine synthetase/guanido kinase, catalytic domain | Glutamine synthetase, N-terminal conserved site | Glutamine synthetase, N-terminal domain | Glutamine synthetase, N-terminal domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T2P7
|
371 |
Interactions and Pathways
No data available
Plasmids
No data available