Gene

gtf2e2

ID

ZDB-GENE-030131-6794

Name

general transcription factor IIE, polypeptide 2, beta

Symbol

gtf2e2 Nomenclature History

Previous Names

wu:fa05d01

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable DNA binding activity. Predicted to contribute to TFIIH-class transcription factor complex binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77074 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gtf2e2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nonphotosensitive trichothiodystrophy 6	Alliance	Trichothiodystrophy 6, nonphotosensitive	616943

Associated With gtf2e2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003166	Transcription factor TFIIE beta subunit, DNA-binding domain
Domain	IPR040501	TFA2, Winged helix domain 2
Family	IPR016656	Transcription initiation factor TFIIE, beta subunit
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	TFA2, Winged helix domain 2	Transcription factor TFIIE beta subunit, DNA-binding domain	Transcription initiation factor TFIIE, beta subunit	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:Q6NXA3 InterPro	291

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	gtf2e2-201 (1) Ensembl	Ensembl	1,287 nt	Select Tool ZFIN BLAST
mRNA	gtf2e2-202 (1) Ensembl	Ensembl	894 nt	Select Tool ZFIN BLAST
mRNA	gtf2e2-203 (1) Ensembl	Ensembl	5,798 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations