Gene

ints1

ID

ZDB-GENE-030131-6523

Name

integrator complex subunit 1

Symbol

ints1 Nomenclature History

Previous Names

fa14a05
wu:fa14a05 (1)
wu:fa55a06

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to be involved in U2 snRNA 3'-end processing. Predicted to localize to integrator complex. Used to study cataract and neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies. Is expressed in brain and eye. Orthologous to human INTS1 (integrator complex subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Krall et al., 2019

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Krall et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ints1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies	Alliance	Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies	618571

Associated With ints1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cataract	ints1^s4002b/+; ints1^s4002a/+	standard conditions	Krall et al., 2019
neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies	ints1^s4002b/+; ints1^s4002a/+	standard conditions	Krall et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR022145	Integrator complex subunit 1, RPB2-binding domain
Domain	IPR053964	Integrator complex subunit 1, R3 domain
Domain	IPR053965	Integrator complex subunit 1, R4 domain
Domain	IPR053966	Integrator complex subunit 1, INTS2-binding domain
Family	IPR038902	Integrator complex subunit 1
Homologous_superfamily	IPR016024	Armadillo-type fold

Domain Details Per Protein

Protein	Length	Armadillo-type fold	Integrator complex subunit 1	Integrator complex subunit 1, INTS2-binding domain	Integrator complex subunit 1, R3 domain	Integrator complex subunit 1, R4 domain	Integrator complex subunit 1, RPB2-binding domain
UniProtKB:A0A0R4IJ75 InterPro	2192

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ints1-201 (1) Ensembl	Ensembl		6,866 nt	Select Tool
mRNA	ints1-202 (1) Ensembl	Ensembl		6,579 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations