Gene

eprs1

ID

ZDB-GENE-030131-638

Name

glutamyl-prolyl-tRNA synthetase 1

Symbol

eprs1 Nomenclature History

Previous Names

eprs
wu:fb06c03
wu:fb38d08
wu:ft34d10

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to localize to aminoacyl-tRNA synthetase multienzyme complex and cytoplasm. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145319 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eprs1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypomyelinating leukodystrophy 15	Alliance	Leukodystrophy, hypomyelinating, 15	617951

Associated With eprs1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Domain	IPR000738	WHEP-TRS domain
Domain	IPR002314	Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain	IPR004046	Glutathione S-transferase, C-terminal
Domain	IPR004154	Anticodon-binding
Domain	IPR006195	Aminoacyl-tRNA synthetase, class II
Domain	IPR010987	Glutathione S-transferase, C-terminal-like
Domain	IPR016061	Proline-tRNA ligase, class II, C-terminal
Domain	IPR020058	Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain
Domain	IPR020059	Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain
Domain	IPR033721	Prolyl-tRNA synthetase, catalytic domain
Domain	IPR049437	tRNA synthetases class I (E and Q), anti-codon binding domain
Family	IPR000924	Glutamyl/glutaminyl-tRNA synthetase
Family	IPR004499	Proline-tRNA ligase, class IIa, archaeal-type
Family	IPR004526	Glutamyl-tRNA synthetase, archaeal/eukaryotic cytosolic
Homologous_superfamily	IPR009068	uS15/NS1, RNA-binding domain superfamily
Homologous_superfamily	IPR011035	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, anti-codon-binding domain superfamily
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR017449	Prolyl-tRNA synthetase, class II
Homologous_superfamily	IPR020056	Large ribosomal subunit protein bL25/Gln-tRNA synthetase, N-terminal
Homologous_superfamily	IPR020061	Glutamine-tRNA ligase, alpha-bundle domain superfamily
Homologous_superfamily	IPR036282	Glutathione S-transferase, C-terminal domain superfamily
Homologous_superfamily	IPR036621	Anticodon-binding domain superfamily
Homologous_superfamily	IPR045864	Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)