Gene

sh3rf1

ID

ZDB-GENE-030131-6288

Name

SH3 domain containing ring finger 1

Symbol

sh3rf1 Nomenclature History

Previous Names

fi42f11
si:ch211-114c9.2
si:dkey-15j16.4
wu:fi42f11

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to have MAP-kinase scaffold activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of alpha-beta T cell activation. Predicted to localize to lamellipodium. Orthologous to several human genes including SH3RF1 (SH3 domain containing ring finger 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sh3rf1 Human Ortholog

No data available

Associated With sh3rf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017907	Zinc finger, RING-type, conserved site
Domain	IPR001452	SH3 domain
Domain	IPR001841	Zinc finger, RING-type
Domain	IPR027370	Zinc finger, RING-type, eukaryotic
Domain	IPR035795	E3 ubiquitin-protein ligase SH3RF1, second SH3 domain
Domain	IPR035816	SH3RF1/SH3RF3, fourth SH3 domain
Family	IPR050384	Endophilin/SH3RF
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR036028	SH3-like domain superfamily