Gene

yars2

ID

ZDB-GENE-030131-6268

Name

tyrosyl-tRNA synthetase 2, mitochondrial

Symbol

yars2 Nomenclature History

Previous Names

fi41d10
wu:fi41d10

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable tyrosine-tRNA ligase activity. Predicted to be involved in tRNA aminoacylation. Predicted to act upstream of or within tyrosyl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 2. Orthologous to human YARS2 (tyrosyl-tRNA synthetase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yars2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myopathy, lactic acidosis, and sideroblastic anemia 2	Alliance	Myopathy, lactic acidosis, and sideroblastic anemia 2	613561

Associated With yars2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
Family	IPR002305	Aminoacyl-tRNA synthetase, class Ic
Family	IPR002307	Tyrosine-tRNA ligase
Family	IPR024088	Tyrosine-tRNA ligase, bacterial-type
Family	IPR024107	Tyrosine-tRNA ligase, bacterial-type, type 1
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036986	RNA-binding S4 domain superfamily