Gene
fan1
- ID
- ZDB-GENE-030131-6225
- Name
- FANCD2 and FANCI associated nuclease 1
- Symbol
- fan1 Nomenclature History
- Previous Names
-
- fi39f01
- si:ch211-163b1.2
- si:ch211-201b11.2 (1)
- wu:fd06a07
- wu:fi39f01
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have flap-structured DNA binding activity; nuclease activity; and ubiquitin-dependent protein binding activity. Predicted to be involved in double-strand break repair via homologous recombination; interstrand cross-link repair; and nucleotide-excision repair, DNA incision. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Is expressed in female organism. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1118 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| karyomegalic interstitial nephritis | Alliance | Interstitial nephritis, karyomegalic | 614817 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006642 | Rad18, zinc finger UBZ4-type |
| Domain | IPR014883 | VRR-NUC domain |
| Domain | IPR049125 | Fanconi-associated nuclease 1-like, winged-helix domain |
| Domain | IPR049126 | Fanconi-associated nuclease 1-like, TPR domain |
| Domain | IPR049138 | Fanconi-associated nuclease 1, SAP subdomain, metazoa |
| Family | IPR033315 | Fanconi-associated nuclease 1-like |
| Family | IPR049132 | Fanconi-associated nuclease 1-like, eukaryotes |
| Homologous_superfamily | IPR011856 | tRNA endonuclease-like domain superfamily |
| Homologous_superfamily | IPR011990 | Tetratricopeptide-like helical domain superfamily |
Domain Details Per Protein
| Protein | Length | Fanconi-associated nuclease 1-like | Fanconi-associated nuclease 1-like, eukaryotes | Fanconi-associated nuclease 1-like, TPR domain | Fanconi-associated nuclease 1-like, winged-helix domain | Fanconi-associated nuclease 1, SAP subdomain, metazoa | Rad18, zinc finger UBZ4-type | Tetratricopeptide-like helical domain superfamily | tRNA endonuclease-like domain superfamily | VRR-NUC domain |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1LWH4
|
988 |
Interactions and Pathways
No data available
Plasmids