Gene

pls1

ID

ZDB-GENE-030131-6205

Name

plastin 1 (I isoform)

Symbol

pls1 Nomenclature History

Previous Names

wu:fi38g03
zgc:63494

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Predicted to localize to actin filament; actin filament bundle; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Is expressed in macrophage; otic vesicle; pronephros; sensory system; and solid lens vesicle. Orthologous to human PLS1 (plastin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63494 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pls1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 76	Alliance	Deafness, autosomal dominant 76	618787

Associated With pls1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Conserved_site	IPR001589	Actinin-type actin-binding domain, conserved site
Domain	IPR001715	Calponin homology domain
Domain	IPR002048	EF-hand domain
Family	IPR039959	Fimbrin/Plastin
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR036872	CH domain superfamily