Gene

mat1a

ID

ZDB-GENE-030131-6127

Name

methionine adenosyltransferase 1A

Symbol

mat1a Nomenclature History

Previous Names

wu:fi35e01

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process and one-carbon metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypermethioninemia. Is expressed in several structures, including anterior neural tube; lens; liver; optic cup; and yolk syncytial layer. Orthologous to human MAT1A (methionine adenosyltransferase 1A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55442 (9 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mat1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency	250850
		Methionine adenosyltransferase deficiency, autosomal recessive	250850

Associated With mat1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022631	S-adenosylmethionine synthetase, conserved site
Domain	IPR022628	S-adenosylmethionine synthetase, N-terminal
Domain	IPR022629	S-adenosylmethionine synthetase, central domain
Domain	IPR022630	S-adenosylmethionine synthetase, C-terminal
Family	IPR002133	S-adenosylmethionine synthetase
Homologous_superfamily	IPR022636	S-adenosylmethionine synthetase superfamily