Gene
ash1l
- ID
- ZDB-GENE-030131-6101
- Name
- ash1 (absent, small, or homeotic)-like (Drosophila)
- Symbol
- ash1l Nomenclature History
- Previous Names
-
- fi34d11
- si:ch211-81a5.3
- wu:fi34d11
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have several functions, including chromatin binding activity; histone-lysine N-methyltransferase activity; and metal ion binding activity. Predicted to be involved in chromatin remodeling. Predicted to localize to RSC-type complex. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 52 | Alliance | Intellectual developmental disorder, autosomal dominant 52 | 617796 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017956 | AT hook, DNA-binding motif |
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR043319 | ASH1-like, PHD finger |
| Domain | IPR043320 | ASH1-like, Bromodomain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR043151 | Bromo adjacent homology (BAH) domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | ASH1-like, Bromodomain | ASH1-like, PHD finger | AT hook, DNA-binding motif | AWS domain | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | Post-SET domain | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QY85
|
2962 | ||||||||||||||||
|
UniProtKB:A0A8M2B6D3
|
2988 |
Interactions and Pathways
No data available
Plasmids
No data available