Gene
ash1l
- ID
- ZDB-GENE-030131-6101
- Name
- ash1 (absent, small, or homeotic)-like (Drosophila)
- Symbol
- ash1l Nomenclature History
- Previous Names
-
- fi34d11
- si:ch211-81a5.3
- wu:fi34d11
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be located in chromosome and nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Sun et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 52 | Alliance | Intellectual developmental disorder, autosomal dominant 52 | 617796 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017956 | AT hook, DNA-binding motif |
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001025 | Bromo adjacent homology (BAH) domain |
| Domain | IPR001214 | SET domain |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003616 | Post-SET domain |
| Domain | IPR006560 | AWS domain |
| Domain | IPR043319 | ASH1-like, PHD finger |
| Domain | IPR043320 | ASH1-like, Bromodomain |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Homologous_superfamily | IPR043151 | Bromo adjacent homology (BAH) domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | ASH1-like, Bromodomain | ASH1-like, PHD finger | AT hook, DNA-binding motif | AWS domain | Bromo adjacent homology (BAH) domain | Bromo adjacent homology (BAH) domain superfamily | Bromodomain | Bromodomain, conserved site | Bromodomain-like superfamily | Post-SET domain | SET domain | SET domain superfamily | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QY85
|
2962 | ||||||||||||||||
|
UniProtKB:A0A8M2B6D3
|
2988 |
Interactions and Pathways
No data available
Plasmids
No data available