Gene

ankle2

ID

ZDB-GENE-030131-6090

Name

ankyrin repeat and LEM domain containing 2

Symbol

ankle2 Nomenclature History

Previous Names

fi34a12
si:dkey-215k6.5
wu:fi34a12

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have protein phosphatase 2A binding activity. Predicted to be involved in mitotic nuclear envelope reassembly; negative regulation of phosphorylation; and positive regulation of protein dephosphorylation. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Apridita Sebastian et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ankle2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary autosomal recessive microcephaly 16	Alliance	Microcephaly 16, primary, autosomal recessive	616681

Associated With ankle2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
primary autosomal recessive microcephaly 16	ankle2^oi5/oi5 (AB)	standard conditions	Apridita Sebastian et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003887	LEM domain
Domain	IPR011320	Ribonuclease H1, N-terminal
Domain	IPR035006	Ankyrin repeat and LEM domain-containing protein 2, LEM domain
Homologous_superfamily	IPR011015	LEM/LEM-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Homologous_superfamily	IPR037056	Ribonuclease H1, N-terminal domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat and LEM domain-containing protein 2, LEM domain	Ankyrin repeat-containing domain superfamily	LEM domain	LEM/LEM-like domain superfamily	Ribonuclease H1, N-terminal	Ribonuclease H1, N-terminal domain superfamily
UniProtKB:A2CEB2 InterPro	961

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ankle2-201 (1) Ensembl	Ensembl	3,132 nt	Select Tool ZFIN BLAST
mRNA	ankle2-202 (1) Ensembl	Ensembl	755 nt	Select Tool
mRNA	ankle2-203 (1) Ensembl	Ensembl	3,674 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations