Gene

vwa1

ID

ZDB-GENE-030131-5921

Name

von Willebrand factor A domain containing 1

Symbol

vwa1 Nomenclature History

Previous Names

fi25e07
si:dkey-3p8.6 (1)
wu:fi25e07 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to be involved in growth plate cartilage chondrocyte morphogenesis. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Orthologous to human VWA1 (von Willebrand factor A domain containing 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vwa1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive distal hereditary motor neuronopathy 7	Alliance	Neuronopathy, distal hereditary motor, autosomal recessive 7	619216

Associated With vwa1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
motor neuron disease	vu19Tg + MO2-vwa1	standard conditions	Pagnamenta et al., 2021
motor neuron disease	vu19Tg + CRISPR5-vwa1 + CRISPR6-vwa1	standard conditions	Pagnamenta et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002035	von Willebrand factor, type A
Domain	IPR003961	Fibronectin type III
Family	IPR050525	Extracellular Matrix Assembly and Organization
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036465	von Willebrand factor A-like domain superfamily

Domain Details Per Protein

Protein	Length	Extracellular Matrix Assembly and Organization	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin-like fold	von Willebrand factor A-like domain superfamily	von Willebrand factor, type A
UniProtKB:E7FF10 InterPro	503

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	vwa1-201 (1) Ensembl	Ensembl	1,980 nt	Select Tool ZFIN BLAST
mRNA	vwa1-203 (1) Ensembl	Ensembl	734 nt	Select Tool ZFIN BLAST
mRNA	vwa1-204 (1) Ensembl	Ensembl	5,483 nt	Select Tool ZFIN BLAST
ncRNA	vwa1-003 (1) Ensembl	Ensembl	630 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations