Gene
kcnd3
- ID
- ZDB-GENE-030131-5626
- Name
- potassium voltage-gated channel, Shal-related subfamily, member 3
- Symbol
- kcnd3 Nomenclature History
- Previous Names
-
- wu:fi06g01
- zgc:55306
- zShal3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Exhibits voltage-gated potassium channel activity. Predicted to contribute to A-type (transient outward) potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to localize to dendrite; neuronal cell body; and voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Is expressed in nervous system. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55306 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Brugada syndrome 9 | Alliance | Brugada syndrome 9 | 616399 |
| spinocerebellar ataxia type 19/22 | Alliance | Spinocerebellar ataxia 19 | 607346 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR021645 | Shal-type voltage-gated potassium channels, N-terminal |
| Domain | IPR024587 | Potassium channel, voltage dependent, Kv4, C-terminal |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003975 | Potassium channel, voltage dependent, Kv4 |
| Family | IPR004056 | Potassium channel, voltage dependent, Kv4.3 |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv4 | Potassium channel, voltage dependent, Kv4.3 | Potassium channel, voltage dependent, Kv4, C-terminal | Shal-type voltage-gated potassium channels, N-terminal | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BF04
|
649 | ||||||||||
|
UniProtKB:Q7ZW36
|
638 | ||||||||||
|
UniProtKB:A0A286Y962
|
650 |
Interactions and Pathways
No data available
Plasmids
No data available