Gene

keap1a

ID

ZDB-GENE-030131-556

Name

kelch-like ECH-associated protein 1a

Symbol

keap1a Nomenclature History

Previous Names

keap1
klhl19 (1)
wu:fb36f11 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Involved in cellular protein metabolic process; cellular response to prostaglandin stimulus; and cellular response to xenobiotic stimulus. Predicted to localize to cytoplasm and inclusion body. Human ortholog(s) of this gene implicated in gallbladder cancer. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human KEAP1 (kelch like ECH associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nguyen et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With keap1a Human Ortholog

No data available

Associated With keap1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR030563	Kelch-like ECH-associated protein 1, BTB/POZ domain
Domain	IPR047098	Kelch-like ECH-associated protein 1, BACK domain
Family	IPR017096	BTB-kelch protein
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Repeat	IPR006652	Kelch repeat type 1