Gene
eif2s3
- ID
- ZDB-GENE-030131-5552
- Name
- eukaryotic translation initiation factor 2, subunit 3 gamma
- Symbol
- eif2s3 Nomenclature History
- Previous Names
-
- eukaryotic translation initiation factor 2 gamma (1)
- fi03g03
- wu:fi03g03
- wu:fi37d04
- zgc:63805
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to localize to cytosol and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63805 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MEHMO syndrome | Alliance | MEHMO syndrome | 300148 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000795 | Translational (tr)-type GTP-binding domain |
| Domain | IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| Domain | IPR015256 | Initiation factor eIF2 gamma, C-terminal |
| Domain | IPR044127 | Initiation factor eIF2 gamma, domain 2 |
| Domain | IPR044128 | Initiation factor eIF2 gamma, GTP-binding domain |
| Family | IPR050543 | Eukaryotic Initiation Factor 2 Gamma Subunit |
| Homologous_superfamily | IPR009000 | Translation protein, beta-barrel domain superfamily |
| Homologous_superfamily | IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | Eukaryotic Initiation Factor 2 Gamma Subunit | Initiation factor eIF2 gamma, C-terminal | Initiation factor eIF2 gamma, domain 2 | Initiation factor eIF2 gamma, GTP-binding domain | P-loop containing nucleoside triphosphate hydrolase | Translational (tr)-type GTP-binding domain | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal | Translation elongation factor EFTu-like, domain 2 | Translation protein, beta-barrel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QGW6
|
472 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
eif2s3-201
(1)
|
Ensembl | 2,112 nt | ||
| mRNA |
eif2s3-202
(1)
|
Ensembl | 839 nt | ||
| mRNA |
eif2s3-203
(1)
|
Ensembl | 884 nt | ||
| ncRNA |
eif2s3-004
(1)
|
Ensembl | 274 nt |
Interactions and Pathways
No data available
Plasmids
No data available