Gene

ago4

ID

ZDB-GENE-030131-5357

Name

argonaute RISC component 4

Symbol

ago4 Nomenclature History

Previous Names

Ago4 (1)
eif2c4
fd14f04
wu:fd14f04

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have miRNA binding activity. Predicted to be involved in miRNA mediated inhibition of translation. Predicted to localize to P-body and RISC complex. Is expressed in several structures, including eye; fin; integument; pleuroperitoneal region; and somite. Orthologous to human AGO4 (argonaute RISC component 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ago4 Human Ortholog

No data available

Associated With ago4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003100	PAZ domain
Domain	IPR003165	Piwi domain
Domain	IPR014811	Argonaute, linker 1 domain
Domain	IPR032472	Argonaute linker 2 domain
Domain	IPR032473	Protein argonaute, Mid domain
Domain	IPR032474	Protein argonaute, N-terminal
Domain	IPR045246	Argonaute-like, PIWI domain
Family	IPR028604	Protein argonaute-4
Homologous_superfamily	IPR012337	Ribonuclease H-like superfamily
Homologous_superfamily	IPR036085	PAZ domain superfamily
Homologous_superfamily	IPR036397	Ribonuclease H superfamily

Domain Details Per Protein

Protein	Length	Argonaute-like, PIWI domain	Argonaute, linker 1 domain	Argonaute linker 2 domain	PAZ domain	PAZ domain superfamily	Piwi domain	Protein argonaute-4	Protein argonaute, Mid domain	Protein argonaute, N-terminal	Ribonuclease H-like superfamily	Ribonuclease H superfamily
UniProtKB:K4IAH1 InterPro	863

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ago4-201 (1) Ensembl	Ensembl		2,877 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations