Gene

polr1a

ID

ZDB-GENE-030131-5286

Name

RNA polymerase I subunit A

Symbol

polr1a Nomenclature History

Previous Names

fa26a03
sb:cb935
wu:fa26a03

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to contribute to RNA polymerase I activity. Involved in embryonic viscerocranium morphogenesis and neural crest cell development. Predicted to localize to RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin musculature; and segmental plate. Orthologous to human POLR1A (RNA polymerase I subunit A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb935 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With polr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acrofacial dysostosis Cincinnati type	Alliance	Acrofacial dysostosis, Cincinnati type	616462
		Leukodystrophy, hypomyelinating, 27	620675

Associated With polr1a Via Experimental Models

Human Disease	Fish	Conditions	Citations
acrofacial dysostosis Cincinnati type	polr1a^{hi3639Tg/hi3639Tg}	control	Watt et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000722	RNA polymerase, alpha subunit
Domain	IPR006592	RNA polymerase, N-terminal
Domain	IPR007066	RNA polymerase Rpb1, domain 3
Domain	IPR007080	RNA polymerase Rpb1, domain 1
Domain	IPR007081	RNA polymerase Rpb1, domain 5
Domain	IPR007083	RNA polymerase Rpb1, domain 4
Domain	IPR015699	DNA-directed RNA pol I, largest subunit, N-terminal domain
Domain	IPR047107	DNA-directed RNA pol I, largest subunit, C-terminal domain
Family	IPR045867	DNA-directed RNA polymerase, subunit beta-prime
Homologous_superfamily	IPR038120	RNA polymerase Rpb1, funnel domain superfamily
Homologous_superfamily	IPR042102	RNA polymerase Rpb1, domain 3 superfamily
Homologous_superfamily	IPR044893	RNA polymerase Rpb1, clamp domain superfamily

Domain Details Per Protein

Protein	Length	DNA-directed RNA pol I, largest subunit, C-terminal domain	DNA-directed RNA pol I, largest subunit, N-terminal domain	DNA-directed RNA polymerase, subunit beta-prime	RNA polymerase, alpha subunit	RNA polymerase, N-terminal	RNA polymerase Rpb1, clamp domain superfamily	RNA polymerase Rpb1, domain 1	RNA polymerase Rpb1, domain 3	RNA polymerase Rpb1, domain 3 superfamily	RNA polymerase Rpb1, domain 4	RNA polymerase Rpb1, domain 5	RNA polymerase Rpb1, funnel domain superfamily
UniProtKB:A0A0R4I9V4 InterPro	1693

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	polr1a-201 (1) Ensembl	Ensembl		5,286 nt	Select Tool ZFIN BLAST
mRNA	polr1a-202 (1) Ensembl	Ensembl		7,583 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations