Gene

ak2

ID

ZDB-GENE-030131-512

Name

adenylate kinase 2

Symbol

ak2 Nomenclature History

Previous Names

wu:fb34f05
wu:fj80e03

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable adenylate kinase activity. Acts upstream of or within hematopoietic stem cell differentiation and leukocyte differentiation. Predicted to be located in mitochondrial intermembrane space. Predicted to be active in mitochondrion. Is expressed in head; hematopoietic system; intermediate cell mass of mesoderm; and otic vesicle. Used to study reticular dysgenesis. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63946 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ak2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
reticular dysgenesis	Alliance	Reticular dysgenesis	267500

Associated With ak2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
reticular dysgenesis	ak2^hg16/hg16	control	(2)
reticular dysgenesis	ak2^hg15/hg15	control	Rissone et al., 2019
reticular dysgenesis	ak2^hg14/hg14	control	(2)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR033690	Adenylate kinase, conserved site
Domain	IPR007862	Adenylate kinase, active site lid domain
Family	IPR000850	Adenylate kinase/UMP-CMP kinase
Family	IPR006259	Adenylate kinase subfamily
Family	IPR028587	Adenylate kinase 2
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	Adenylate kinase 2	Adenylate kinase, active site lid domain	Adenylate kinase, conserved site	Adenylate kinase subfamily	Adenylate kinase/UMP-CMP kinase	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q1L8L9 InterPro	241
UniProtKB:A0A0F6PK88 InterPro	235

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ak2-201 (1) Ensembl	Ensembl	1,478 nt	Select Tool ZFIN BLAST
mRNA	ak2-203 (1) Ensembl	Ensembl	856 nt	Select Tool ZFIN BLAST
ncRNA	ak2-002 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations