Gene

rasa1a

ID

ZDB-GENE-030131-4694

Name

RAS p21 protein activator (GTPase activating protein) 1a

Symbol

rasa1a Nomenclature History

Previous Names

rasa1
fd52c05
si:dkey-195m1.3
wu:fd52c05

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to have GTPase activator activity. Involved in blood vessel development and ephrin receptor signaling pathway. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Is expressed in head. Orthologous to human RASA1 (RAS p21 protein activator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Kawasaki et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rasa1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Basal cell carcinoma, somatic	605462
		Capillary malformation-arteriovenous malformation 1	608354

Associated With rasa1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023152	Ras GTPase-activating protein, conserved site
Domain	IPR000008	C2 domain
Domain	IPR000980	SH2 domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR001936	Ras GTPase-activating domain
Domain	IPR035652	RasGAP, SH3 domain
Domain	IPR035841	Ras GTPase-activating protein 1, N-terminal SH2 domain
Domain	IPR035842	Ras GTPase-activating protein 1, C-terminal SH2 domain
Family	IPR039360	Ras GTPase-activating protein
Homologous_superfamily	IPR008936	Rho GTPase activation protein
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PH-like domain superfamily	Pleckstrin homology domain	RasGAP, SH3 domain	Ras GTPase-activating domain	Ras GTPase-activating protein	Ras GTPase-activating protein 1, C-terminal SH2 domain	Ras GTPase-activating protein 1, N-terminal SH2 domain	Ras GTPase-activating protein, conserved site	Rho GTPase activation protein	SH2 domain	SH2 domain superfamily	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9Q9R0 InterPro	892
UniProtKB:F1R3X3 InterPro	1010

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rasa1a-201 (1) Ensembl	Ensembl	3,033 nt	Select Tool ZFIN BLAST
mRNA	rasa1a-202 (1) Ensembl	Ensembl	4,309 nt	Select Tool
mRNA	rasa1a-203 (1) Ensembl	Ensembl	578 nt	Select Tool
ncRNA	rasa1a-003 (1) Ensembl	Ensembl	667 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations