Gene

chd4b

ID

ZDB-GENE-030131-4532

Name

chromodomain helicase DNA binding protein 4b

Symbol

chd4b Nomenclature History

Previous Names

si:ch211-57k11.10
wu:fb44b12
wu:fd12d03 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have ATP binding activity and metal ion binding activity. Predicted to localize to nucleus. Is expressed in blastomere and central nervous system. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chd4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Sifrim-Hitz-Weiss syndrome	Alliance	Sifrim-Hitz-Weiss syndrome	617159

Associated With chd4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR000330	SNF2, N-terminal
Domain	IPR000953	Chromo/chromo shadow domain
Domain	IPR001650	Helicase, C-terminal domain-like
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR009462	CHD subfamily II, SANT-like domain
Domain	IPR009463	Domain of unknown function DUF1087
Domain	IPR012957	CHD, C-terminal 2
Domain	IPR012958	CHD, N-terminal
Domain	IPR014001	Helicase superfamily 1/2, ATP-binding domain
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR023780	Chromo domain
Domain	IPR049730	SNF2/RAD5-like, C-terminal helicase domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR016197	Chromo-like domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR038718	SNF2-like, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	CHD, C-terminal 2	CHD, N-terminal	CHD subfamily II, SANT-like domain	Chromo/chromo shadow domain	Chromo domain	Chromo-like domain superfamily	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site	Domain of unknown function DUF1087	Helicase, C-terminal domain-like	Helicase superfamily 1/2, ATP-binding domain	P-loop containing nucleoside triphosphate hydrolase	SNF2-like, N-terminal domain superfamily	SNF2, N-terminal	SNF2/RAD5-like, C-terminal helicase domain	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M9PC64 InterPro	1948
UniProtKB:A0A8M9PNR4 InterPro	1890
UniProtKB:A0A8M9PDP3 InterPro	1949
UniProtKB:A0A8N7T760 InterPro	1952
UniProtKB:F1RBT2 InterPro	1953
UniProtKB:A0A8M9PN35 InterPro	1891

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	chd4b-201 (1) Ensembl	Ensembl		7,365 nt	Select Tool
mRNA	chd4b-202 (1) Ensembl	Ensembl		7,984 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations