Gene

greb1l

ID

ZDB-GENE-030131-4022

Name

GREB1 like retinoic acid receptor coactivator

Symbol

greb1l Nomenclature History

Previous Names

fc65f09
si:dkey-203o21.1
si:dkey-264l15.1
wu:fc55e03
wu:fc65f09 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Involved in pronephros development. Predicted to localize to integral component of membrane. Used to study renal agenesis. Human ortholog(s) of this gene implicated in renal agenesis. Is expressed in central nervous system and mesoderm. Orthologous to human GREB1L (GREB1 like retinoic acid receptor coactivator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With greb1l Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 80	Alliance	Deafness, autosomal dominant 80	619274
		Renal hypodysplasia/aplasia 3	617805

Associated With greb1l Via Experimental Models

Human Disease	Fish	Conditions	Citations
renal agenesis	greb1l^{rdu1000/rdu1000}	standard conditions	Sanna-Cherchi et al., 2017
renal agenesis	EKW + MO2-greb1l	standard conditions	Sanna-Cherchi et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR046926	GREB1, N-terminal domain
Domain	IPR046927	GREB1-like, C-terminal domain
Domain	IPR048657	GREB1-like, circularly permuted SF2 helicase domain
Domain	IPR048659	GREB1-like, second domain
Domain	IPR049100	TET-Associated Glycosyltransferase
Family	IPR028422	GREB1

Domain Details Per Protein

Protein	Length	GREB1	GREB1-like, circularly permuted SF2 helicase domain	GREB1-like, C-terminal domain	GREB1-like, second domain	GREB1, N-terminal domain	TET-Associated Glycosyltransferase
UniProtKB:B8JKP6 InterPro	1942
UniProtKB:A0A8M9NZP6 InterPro	1942

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	greb1l-201 (1) Ensembl	Ensembl	8,900 nt	Select Tool ZFIN BLAST
mRNA	greb1l-203 (1) Ensembl	Ensembl	9,009 nt	Select Tool ZFIN BLAST
ncRNA	greb1l-002 (1) Ensembl	Ensembl	851 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl
Note: Woods, et al. (2005. Genome Res. 15:1307-1314.) report this gene to be the ortholog of human GREB1 based on amino acid similarity. Subsequent analysis suggests it is the ortholog of human GREB1L and mouse Greb1l based on amino acid similarity and conserved synteny.

Citations