Gene
tnika
- ID
- ZDB-GENE-030131-3767
- Name
- TRAF2 and NCK interacting kinase a
- Symbol
- tnika Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within convergent extension involved in gastrulation and regulation of cell shape. Predicted to be active in cytoplasm. Is expressed in nervous system and neural tube. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63535 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Koppen et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 54 | Alliance | Intellectual developmental disorder, autosomal recessive 54 | 617028 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001180 | Citron homology (CNH) domain |
| Family | IPR051700 | STE20 Ser/Thr Protein Kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Citron homology (CNH) domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | STE20 Ser/Thr Protein Kinase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BAL9
|
1297 | ||||||
|
UniProtKB:A0A8M2BAG3
|
858 | ||||||
|
UniProtKB:A0A8M2BAK0
|
1326 | ||||||
|
UniProtKB:A0A0R4IEP9
|
1332 | ||||||
|
UniProtKB:Q7SY42
|
1303 | ||||||
|
UniProtKB:A0A8M2BAL6
|
1419 | ||||||
|
UniProtKB:A0A8M2BAT5
|
1390 | ||||||
|
UniProtKB:A0A8M2BAF9
|
1413 |
Interactions and Pathways
No data available
Plasmids
No data available