Gene

mylk3

ID

ZDB-GENE-030131-3497

Name

myosin light chain kinase 3

Symbol

mylk3 Nomenclature History

Previous Names

mlck (1)
cardiac-MLCK (1)
fc41h03
si:rp71-34g2.1
wu:fc41h03 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to enable myosin light chain kinase activity. Involved in sarcomerogenesis and ventricular cardiac myofibril assembly. Acts upstream of or within heart morphogenesis. Predicted to be located in cytoplasm. Is expressed in lens; notochord; pericardial region; and somite. Orthologous to human MYLK3 (myosin light chain kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Seguchi et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mylk3 Human Ortholog

No data available

Associated With mylk3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily