Gene
wdr81
- ID
- ZDB-GENE-030131-3389
- Name
- WD repeat domain 81
- Symbol
- wdr81 Nomenclature History
- Previous Names
-
- fc37g06
- wu:fc37g06
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol 3-kinase regulator activity. Predicted to be involved in several processes, including aggrephagy; early endosome to late endosome transport; and regulation of phosphatidylinositol 3-kinase activity. Predicted to be located in bounding membrane of organelle and cytosol. Predicted to be extrinsic component of endosome membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including heart; liver; nervous system; optic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 | Alliance | Cerebellar ataxia, impaired intellectual development, and dysquilibrium syndrome 2 | 610185 |
| Hydrocephalus, congenital, 3, with brain anomalies | 617967 |
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance