Gene

cpsf3

ID

ZDB-GENE-030131-3275

Name

cleavage and polyadenylation specific factor 3

Symbol

cpsf3 Nomenclature History

Previous Names

si:dkey-81b15.1
wu:fc32f10
zgc:101655

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Predicted to enable 5'-3' exonuclease activity; RNA binding activity; and endoribonuclease activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and mRNA polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6906113 (1 image)
IMAGE:7155771 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cpsf3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures	619876

Associated With cpsf3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001279	Metallo-beta-lactamase
Domain	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain
Domain	IPR021718	Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Domain	IPR022712	Beta-Casp domain
Family	IPR050698	RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein
Homologous_superfamily	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

Domain Details Per Protein

Protein	Length	Beta-Casp domain	Metallo-beta-lactamase	Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein	Zn-dependent metallo-hydrolase, RNA specificity domain
UniProtKB:Q6DRG6 InterPro	690

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cpsf3-201 (1) Ensembl	Ensembl	2,576 nt	Select Tool ZFIN BLAST
ncRNA	cpsf3-002 (1) Ensembl	Ensembl	501 nt	Select Tool ZFIN BLAST
ncRNA	cpsf3-003 (1) Ensembl	Ensembl	687 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations