Gene

apoa4b.2

ID

ZDB-GENE-030131-3143

Name

apolipoprotein A-IV b, tandem duplicate 2

Symbol

apoa4b.2 Nomenclature History

Previous Names

fc28d04
wu:fc10a03
wu:fc28d04 (1)
zgc:194131

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to enable cholesterol transfer activity; phosphatidylcholine-sterol O-acyltransferase activator activity; and phospholipid binding activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within lipid transport and lipoprotein metabolic process. Predicted to be located in extracellular region. Predicted to be part of several cellular components, including chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in extracellular vesicle. Is expressed in ball; extension; intestine; yolk; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apoa4b.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Tubulointerstitial kidney disease, autosomal dominant 6	621106

Associated With apoa4b.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000074	Apolipoprotein A/E
Family	IPR050163	Apolipoprotein A1/A4/E

Domain Details Per Protein

Protein	Length	Apolipoprotein A1/A4/E	Apolipoprotein A/E
UniProtKB:A0A8M9NZC6 InterPro	314
UniProtKB:B3DHC5 InterPro	255
UniProtKB:F1QJD1 InterPro	255

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	apoa4b.2-201 (1) Ensembl	Ensembl	970 nt	Select Tool ZFIN BLAST
mRNA	apoa4b.2-202 (1) Ensembl	Ensembl	811 nt	Select Tool ZFIN BLAST
mRNA	apoa4b.2-203 (1) Ensembl	Ensembl	1,046 nt	Select Tool ZFIN BLAST
mRNA	apoa4b.2-204 (1) Ensembl	Ensembl	588 nt	Select Tool ZFIN BLAST
ncRNA	apoa4b.2-002 (1) Ensembl	Ensembl	617 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Addgene:PCRII apoA-IVb.2

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations