Gene

chsy1

ID

ZDB-GENE-030131-3127

Name

chondroitin sulfate synthase 1

Symbol

chsy1 Nomenclature History

Previous Names

chys1
wu:fc27h05
wu:fc27h06
zgc:64191

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have acetylgalactosaminyltransferase activity. Involved in several processes, including animal organ morphogenesis; chondroitin sulfate proteoglycan biosynthetic process; and regulation of Notch signaling pathway. Predicted to localize to Golgi cisterna membrane and integral component of membrane. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Is expressed in several structures, including cranium; forerunner cell group; inner ear; optic primordium; and pectoral fin bud. Orthologous to human CHSY1 (chondroitin sulfate synthase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:64191 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chsy1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
temtamy preaxial brachydactyly syndrome	Alliance	Temtamy preaxial brachydactyly syndrome	605282

Associated With chsy1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008428	Chondroitin N-acetylgalactosaminyltransferase
Family	IPR051227	Chondroitin sulfate glycosyltransferase
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases