Gene

tle2a

ID

ZDB-GENE-030131-2826

Name

TLE family member 2, transcriptional corepressor a

Symbol

tle2a Nomenclature History

Previous Names

tle2 (1)
fc18h03
sb:eu1034
sb:eu408
si:ch211-81i17.1
wu:fb96a10
wu:fc18h03

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in oocyte; telencephalon; and unfertilized egg. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu825 (1 image)
eu856 (1 image)
eu408 (1 image)
eu1034 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tle2a Human Ortholog

No data available

Associated With tle2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR005617	Groucho/TLE, N-terminal Q-rich domain
Family	IPR009146	Groucho/transducin-like enhancer
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Length	Groucho/TLE, N-terminal Q-rich domain	Groucho/transducin-like enhancer	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:B3DJR5 InterPro	811
UniProtKB:A0A8M2BI83 InterPro	790
UniProtKB:A0A8M2BHU5 InterPro	801
UniProtKB:A0A8M3B5J1 InterPro	786
UniProtKB:A0A8M2BHT3 InterPro	796

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tle2a-202 (1) Ensembl	Ensembl	3,739 nt	Select Tool ZFIN BLAST
ncRNA	tle2-002 (1) Ensembl	Ensembl	597 nt	Select Tool ZFIN BLAST
ncRNA	tle2-003 (1) Ensembl	Ensembl	568 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations