Gene

dyrk2

ID

ZDB-GENE-030131-2804

Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Symbol

dyrk2 Nomenclature History

Previous Names

fc18c09
si:ch211-266a5.8
wu:fa09g03
wu:fc18c09

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to localize to cytoplasm; cytoskeleton; and nucleus. Is expressed in central nervous system; myotome; and spinal cord. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Tanaka et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dyrk2 Human Ortholog

No data available

Associated With dyrk2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050494	Serine/threonine and dual-specificity kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR042521	Dual specificity tyrosine-phosphorylation-regulated kinase

Domain Details Per Protein

Protein	Length	Dual specificity tyrosine-phosphorylation-regulated kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine and dual-specificity kinase	Serine/threonine-protein kinase, active site
UniProtKB:A0A0R4ITS5 InterPro	598
UniProtKB:Q5RHV3 InterPro	587
UniProtKB:A0A2R8QCS7 InterPro	577

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dyrk2-202 (1) Ensembl	Ensembl	5,073 nt	Select Tool ZFIN BLAST
mRNA	dyrk2-203 (1) Ensembl	Ensembl	6,221 nt	Select Tool ZFIN BLAST
mRNA	dyrk2-204 (1) Ensembl	Ensembl	5,902 nt	Select Tool ZFIN BLAST
ncRNA	dyrk2-002 (1) Ensembl	Ensembl	4,704 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations