Gene

add3a

ID

ZDB-GENE-030131-2721

Name

adducin 3 (gamma) a

Symbol

add3a Nomenclature History

Previous Names

add3
wu:fb38g03
wu:fc16e06
zgc:55560
zgc:77226

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Involved in hepaticobiliary system development. Predicted to localize to cytoskeleton; plasma membrane raft; and postsynaptic density. Used to study biliary atresia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Is expressed in head; liver; pericardial region; and pleuroperitoneal region. Orthologous to human ADD3 (adducin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With add3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spastic quadriplegic cerebral palsy 3	Alliance	Cerebral palsy, spastic quadriplegic, 3	617008

Associated With add3a Via Experimental Models

Human Disease	Fish	Conditions	Citations
biliary atresia	add3a^sa819/sa819	standard conditions	Tang et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001303	Class II aldolase/adducin N-terminal
Family	IPR051017	Aldolase class II Adducin subfamily
Homologous_superfamily	IPR036409	Class II aldolase/adducin N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Aldolase class II Adducin subfamily	Class II aldolase/adducin N-terminal	Class II aldolase/adducin N-terminal domain superfamily
UniProtKB:A0A8M6YXA3 InterPro	677
UniProtKB:Q1LUP1 InterPro	672
UniProtKB:A0A2R8QBF8 InterPro	671
UniProtKB:Q1LUP2 InterPro	645
UniProtKB:Q7ZUA1 InterPro	672
UniProtKB:A0A8M6Z434 InterPro	651
UniProtKB:A0A2R8Q5P5 InterPro	678

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	add3a-201 (1) Ensembl	Ensembl	2,502 nt	Select Tool ZFIN BLAST
mRNA	add3a-202 (1) Ensembl	Ensembl	3,671 nt	Select Tool ZFIN BLAST
mRNA	add3a-203 (1) Ensembl	Ensembl	3,494 nt	Select Tool ZFIN BLAST
mRNA	add3a-205 (1) Ensembl	Ensembl	871 nt	Select Tool ZFIN BLAST
mRNA	add3a-206 (1) Ensembl	Ensembl	612 nt	Select Tool ZFIN BLAST
mRNA	add3a-207 (1) Ensembl	Ensembl	570 nt	Select Tool ZFIN BLAST
mRNA	add3a-208 (1) Ensembl	Ensembl	2,044 nt	Select Tool ZFIN BLAST
mRNA	add3a-209 (1) Ensembl	Ensembl	2,148 nt	Select Tool ZFIN BLAST
mRNA	add3a-210 (1) Ensembl	Ensembl	2,661 nt	Select Tool ZFIN BLAST
mRNA	add3a-211 (1) Ensembl	Ensembl	2,261 nt	Select Tool ZFIN BLAST
mRNA	add3a-212 (1) Ensembl	Ensembl	3,034 nt	Select Tool ZFIN BLAST
ncRNA	add3a-005 (1) Ensembl	Ensembl	849 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations