Gene

add3a

ID

ZDB-GENE-030131-2721

Name

adducin 3 (gamma) a

Symbol

add3a Nomenclature History

Previous Names

add3
wu:fb38g03
wu:fc16e06
zgc:55560
zgc:77226

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity; spectrin binding activity; and structural molecule activity. Involved in hepaticobiliary system development. Predicted to localize to cytoskeleton; plasma membrane raft; and postsynaptic density. Used to study biliary atresia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 50. Is expressed in head; liver; pericardial region; and pleuroperitoneal region. Orthologous to human ADD3 (adducin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With add3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spastic quadriplegic cerebral palsy 3	Alliance	Cerebral palsy, spastic quadriplegic, 3	617008

Associated With add3a Via Experimental Models

Human Disease	Fish	Conditions	Citations
biliary atresia	add3a^sa819/sa819	standard conditions	Tang et al., 2016

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001303	Class II aldolase/adducin N-terminal
Family	IPR051017	Aldolase class II Adducin subfamily
Homologous_superfamily	IPR036409	Class II aldolase/adducin N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Aldolase class II Adducin subfamily	Class II aldolase/adducin N-terminal	Class II aldolase/adducin N-terminal domain superfamily
UniProtKB:A0A8M6YXA3 InterPro	677
UniProtKB:Q1LUP1 InterPro	672
UniProtKB:A0A2R8QBF8 InterPro	671
UniProtKB:Q1LUP2 InterPro	645
UniProtKB:Q7ZUA1 InterPro	672
UniProtKB:A0A8M6Z434 InterPro	651
UniProtKB:A0A2R8Q5P5 InterPro	678

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	add3a-201 (1) Ensembl	Ensembl	2,502 nt	Select Tool ZFIN BLAST
mRNA	add3a-202 (1) Ensembl	Ensembl	3,671 nt	Select Tool
mRNA	add3a-203 (1) Ensembl	Ensembl	3,494 nt	Select Tool
mRNA	add3a-205 (1) Ensembl	Ensembl	871 nt	Select Tool
mRNA	add3a-206 (1) Ensembl	Ensembl	612 nt	Select Tool
mRNA	add3a-207 (1) Ensembl	Ensembl	570 nt	Select Tool
mRNA	add3a-208 (1) Ensembl	Ensembl	2,044 nt	Select Tool ZFIN BLAST
mRNA	add3a-209 (1) Ensembl	Ensembl	2,148 nt	Select Tool ZFIN BLAST
mRNA	add3a-210 (1) Ensembl	Ensembl	2,661 nt	Select Tool ZFIN BLAST
mRNA	add3a-211 (1) Ensembl	Ensembl	2,261 nt	Select Tool ZFIN BLAST
mRNA	add3a-212 (1) Ensembl	Ensembl	3,034 nt	Select Tool ZFIN BLAST
ncRNA	add3a-005 (1) Ensembl	Ensembl	849 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations