Gene

top2a

ID

ZDB-GENE-030131-2453

Name

DNA topoisomerase II alpha

Symbol

top2a Nomenclature History

Previous Names

fc08c07
wu:fc08c07

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in animal organ regeneration and chromosome segregation. Predicted to localize to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex and nucleus. Is expressed in digestive system; head; nervous system; neural tube; and pectoral fin. Orthologous to human TOP2A (DNA topoisomerase II alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 12 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With top2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		DNA topoisomerase II, resistance to inhibition of, by amsacrine

Associated With top2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018522	DNA topoisomerase, type IIA, conserved site
Domain	IPR002205	DNA topoisomerase, type IIA, domain A
Domain	IPR003594	Histidine kinase/HSP90-like ATPase domain
Domain	IPR006171	TOPRIM domain
Domain	IPR012542	DTHCT
Domain	IPR013506	DNA topoisomerase, type IIA, subunit B, domain 2
Domain	IPR031660	C-terminal associated domain of TOPRIM
Domain	IPR034157	DNA topoisomerase 2, TOPRIM domain
Family	IPR001154	DNA topoisomerase II, eukaryotic-type
Family	IPR001241	DNA topoisomerase, type IIA
Homologous_superfamily	IPR013757	DNA topoisomerase, type IIA, alpha-helical domain superfamily
Homologous_superfamily	IPR013758	DNA topoisomerase, type IIA, domain A, alpha-beta
Homologous_superfamily	IPR013759	DNA topoisomerase, type IIA, subunit B, C-terminal
Homologous_superfamily	IPR013760	DNA topoisomerase, type IIA-like domain superfamily
Homologous_superfamily	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Homologous_superfamily	IPR020568	Ribosomal protein uS5 domain 2-type superfamily
Homologous_superfamily	IPR036890	Histidine kinase/HSP90-like ATPase superfamily