Gene
setdb1a
- ID
- ZDB-GENE-030131-2421
- Name
- SET domain bifurcated histone lysine methyltransferase 1a
- Symbol
- setdb1a Nomenclature History
- Previous Names
-
- fc07d03
- si:ch211-81a5.6
- wu:fc07d03
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have histone methyltransferase activity (H3-K9 specific) and promoter-specific chromatin binding activity. Predicted to be involved in Ras protein signal transduction; chromatin organization; and regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001214 | SET domain |
| Domain | IPR001739 | Methyl-CpG DNA binding |
| Domain | IPR007728 | Pre-SET domain |
| Domain | IPR040880 | Domain of unknown function DUF5604 |
| Domain | IPR041291 | Histone methyltransferase, Tudor domain 1 |
| Domain | IPR041292 | Histone methyltransferase, Tudor domain 2 |
| Domain | IPR047232 | Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains |
| Family | IPR051516 | Histone-lysine N-methyltransferase SETDB |
| Homologous_superfamily | IPR016177 | DNA-binding domain superfamily |
| Homologous_superfamily | IPR046341 | SET domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA-binding domain superfamily | Domain of unknown function DUF5604 | Histone-lysine N-methyltransferase SETDB | Histone-lysine N-methyltransferase SETDB1/2-like, methyl-CpG binding domains | Histone methyltransferase, Tudor domain 1 | Histone methyltransferase, Tudor domain 2 | Methyl-CpG DNA binding | Pre-SET domain | SET domain | SET domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q1L8U8
|
1436 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
setdb1a-201
(1)
|
Ensembl | 7,696 nt | ||
| mRNA |
setdb1a-202
(1)
|
Ensembl | 4,840 nt | ||
| ncRNA |
setdb1a-002
(1)
|
Ensembl | 493 nt |
Interactions and Pathways
No data available
Plasmids
No data available