Gene
vkorc1
- ID
- ZDB-GENE-030131-2286
- Name
- vitamin K epoxide reductase complex, subunit 1
- Symbol
- vkorc1 Nomenclature History
- Previous Names
-
- fc03a11
- si:dkey-32n7.10
- wu:fc03a11 (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have vitamin-K-epoxide reductase (warfarin-sensitive) activity. Predicted to be involved in blood coagulation; peptidyl-glutamic acid carboxylation; and vitamin K metabolic process. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in inherited blood coagulation disease. Is expressed in head. Orthologous to human VKORC1 (vitamin K epoxide reductase complex subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined deficiency of vitamin K-dependent clotting factors 2 | Alliance | Vitamin K-dependent clotting factors, combined deficiency of, 2 | 607473 |
| warfarin resistance | Alliance | Warfarin resistance | 122700 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Vitamin K epoxide reductase | Vitamin K epoxide reductase complex subunit 1 | VKOR domain superfamily |
|---|---|---|---|---|
|
UniProtKB:E7F6X2
|
171 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
vkorc1-201
(1)
|
Ensembl | 863 nt |
Interactions and Pathways
No data available
Plasmids
No data available