Gene
zc4h2
- ID
- ZDB-GENE-030131-2207
- Name
- zinc finger, C4H2 domain containing
- Symbol
- zc4h2 Nomenclature History
- Previous Names
-
- un-named hi2729b
- unm hi2729b
- wu:fb99f08
- zgc:63849
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Involved in neuromuscular junction development; positive regulation of neuron differentiation; and spinal cord motor neuron differentiation. Acts upstream of or within neuron development and neuron fate specification. Located in nucleus. Is expressed in nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in Miles-Carpenter syndrome. Orthologous to human ZC4H2 (zinc finger C4H2-type containing).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63849 (6 images)
- IMAGE:6908809 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| female-restricted Wieacker-Wolff syndrome | Alliance | Wieacker-Wolff syndrome, female-restricted | 301041 |
| Wieacker-Wolff syndrome | Alliance | Wieacker-Wolff syndrome | 314580 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| epilepsy | WT + MO2-zc4h2 | standard conditions | Hwang et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C4H2 domain-containing protein | Zinc finger C4H2-type |
|---|---|---|---|
|
UniProtKB:Q7T3I0
|
224 |
Interactions and Pathways
No data available
Plasmids
No data available