Gene

metap2b

ID

ZDB-GENE-030131-2172

Name

methionyl aminopeptidase 2b

Symbol

metap2b Nomenclature History

Previous Names

metap2
wu:fb98h06
zgc:66250

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity and metalloaminopeptidase activity. Involved in Wnt signaling pathway; definitive hemopoiesis; and hematopoietic stem cell differentiation. Predicted to localize to cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; pronephric duct; and trunk. Orthologous to human METAP2 (methionyl aminopeptidase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7159348 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With metap2b Human Ortholog

No data available

Associated With metap2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018349	Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
Domain	IPR000994	Peptidase M24
Family	IPR001714	Peptidase M24, methionine aminopeptidase
Family	IPR002468	Peptidase M24A, methionine aminopeptidase, subfamily 2
Family	IPR050247	Methionine Aminopeptidase Type 2
Homologous_superfamily	IPR036005	Creatinase/aminopeptidase-like
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily