Gene
ogdha
- ID
- ZDB-GENE-030131-2143
- Name
- oxoglutarate dehydrogenase a
- Symbol
- ogdha Nomenclature History
- Previous Names
-
- ogdh
- im:7045267
- wu:fa06d01
- wu:fb98a04
- zgc:73296
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in heart contraction. Predicted to localize to mitochondrion and oxoglutarate dehydrogenase complex. Is expressed in several structures, including immature eye; lens; mesoderm; musculature system; and pronephric duct. Orthologous to human OGDH (oxoglutarate dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73296 (11 images)
- IMAGE:7146762 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| oxoglutarate dehydrogenase deficiency | Alliance | Oxoglutarate dehydrogenase deficiency | 203740 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001017 | Dehydrogenase, E1 component |
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR031717 | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal |
| Domain | IPR032106 | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain |
| Family | IPR011603 | 2-oxoglutarate dehydrogenase E1 component |
| Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
| Homologous_superfamily | IPR042179 | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | 2-oxoglutarate dehydrogenase E1 component | 2-oxoglutarate dehydrogenase E1 component/KDG, C-terminal | 2-oxoglutarate dehydrogenase E1 component, N-terminal domain | Dehydrogenase, E1 component | Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily | Thiamin diphosphate-binding fold | Transketolase-like, pyrimidine-binding domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BJT5
|
1054 | |||||||
|
UniProtKB:B8JI08
|
1022 | |||||||
|
UniProtKB:F1Q5B8
|
1019 | |||||||
|
UniProtKB:A0A0R4IP01
|
1022 | |||||||
|
UniProtKB:A0A8M3AVG6
|
1037 |
Interactions and Pathways
No data available
Plasmids
No data available